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Peptide record

TPDB47531

ACE inhibitor ACE inhibitors Antihypertensive Bitter Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47531
ACE inhibitor
ACE inhibitors Antihypertensive Bitter Neuropeptide
Cardiometabolic peptides Neuroactive peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GRP
Physicochemical Analysis
C13H24N6O4
ANDCEQHILKMFSTWYV
RGP
328.37
11.05
1
0
0
+1
1.27
-2.167
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H24N6O4
328.37
11.05
+1
1.27
-2.167
328.3665
328.1854
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
19.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
1994
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H24N6O4/c14-7-10(20)18-8(3-1-5-17-13(15)16)11(21)19-6-2-4-9(19)12(22)23/h8-9H,1-7,14H2,(H,18,20)(H,22,23)(H4,15,16,17)/t8-,9-/m0/s1 InChIKey=VXKCPBPQEKKERH-IUCAKERBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
19.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H24N6O4/c14-7-10(20)18-8(3-1-5-17-13(15)16)11(21)19-6-2-4-9(19)12(22)23/h8-9H,1-7,14H2,(H,18,20)(H,22,23)(H4,15,16,17)/t8-,9-/m0/s1 InChIKey=VXKCPBPQEKKERH-IUCAKERBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
3