TPDB

3D PDB MODEL

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TPDB ID TPDB47524

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

ALPHA

FASTA

>TPDB47524|ACE inhibitors;Antihypertensive|length=5
ALPHA

Formula C23H37N7O6

Absent Amino Acids RNDCEQGIKMFSTWYV

Common Amino Acids A

Mass 507.59

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index 0.51

Hydrophobicity 0.520

Aliphatic Index 118.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C23H37N7O6

Mass

507.59

PI

7.85

Net Charge

+0

Boman Index

0.51

Hydrophobicity

0.520

Chemical_Mass

507.5817

Monoisotopic_Mass

507.2797

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 10.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Yokoyama K., Chiba H., Yoshikawa M.

Title

Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992

Year 1992

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C)Cc2[nH]cnc2)CCC1)CC(C)C)C InChI=1S/C23H37N7O6/c1-12(2)8-17(29-19(31)13(3)24)22(34)30-7-5-6-18(30)21(33)28-16(9-15-10-25-11-26-15)20(32)27-14(4)23(35)36/h10-14,16-18H,5-9,24H2,1-4H3,(H,25,26)(H,27,32)(H,28,33)(H,29,31)(H,35,36)/t13-,14-,16-,17-,18-/m0/s1 InChIKey: NIBZGHPXKYHPHI-IAVJCBSLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 10.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Yokoyama K., Chiba H., Yoshikawa M.

Title

Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992

Year 1992

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C)Cc2[nH]cnc2)CCC1)CC(C)C)C InChI=1S/C23H37N7O6/c1-12(2)8-17(29-19(31)13(3)24)22(34)30-7-5-6-18(30)21(33)28-16(9-15-10-25-11-26-15)20(32)27-14(4)23(35)36/h10-14,16-18H,5-9,24H2,1-4H3,(H,25,26)(H,27,32)(H,28,33)(H,29,31)(H,35,36)/t13-,14-,16-,17-,18-/m0/s1 InChIKey: NIBZGHPXKYHPHI-IAVJCBSLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5