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Peptide record

TPDB47523

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47523
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
IWHHT
Physicochemical Analysis
C33H44N10O7
ARNDCEQGLKMFPSYV
H
692.78
8.00
2
0
2
+0
-0.10
-0.700
78.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
793.91
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
5
C33H44N10O7
692.78
8.00
+0
-0.10
-0.700
692.7635
692.3385
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
5.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Yokoyama K., Chiba H., and Yoshikawa M., 1992
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

5
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@H](O)C)Cc1[nH]cnc1)Cc1[nH]cnc1)Cc1c[nH]c2c1cccc2)[C@H](CC)C InChI=1S/C33H44N10O7/c1-4-17(2)27(34)32(48)42-24(9-19-12-37-23-8-6-5-7-22(19)23)29(45)40-25(10-20-13-35-15-38-20)30(46)41-26(11-21-14-36-16-39-21)31(47)43-28(18(3)44)33(49)50/h5-8,12-18,24-28,37,44H,4,9-11,34H2,1-3H3,(H,35,38)(H,36,39)(H,40,45)(H,41,46)(H,42,48)(H,43,47)(H,49,50)/t17-,18+,24-,25-,26-,27-,28-/m0/s1 InChIKey: OLSRROIYCKGQLR-DIRMYTRESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
5.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yokoyama K., Chiba H., and Yoshikawa M., 1992
Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545
1992
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@H](O)C)Cc1[nH]cnc1)Cc1[nH]cnc1)Cc1c[nH]c2c1cccc2)[C@H](CC)C InChI=1S/C33H44N10O7/c1-4-17(2)27(34)32(48)42-24(9-19-12-37-23-8-6-5-7-22(19)23)29(45)40-25(10-20-13-35-15-38-20)30(46)41-26(11-21-14-36-16-39-21)31(47)43-28(18(3)44)33(49)50/h5-8,12-18,24-28,37,44H,4,9-11,34H2,1-3H3,(H,35,38)(H,36,39)(H,40,45)(H,41,46)(H,42,48)(H,43,47)(H,49,50)/t17-,18+,24-,25-,26-,27-,28-/m0/s1 InChIKey: OLSRROIYCKGQLR-DIRMYTRESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
5