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Peptide record

TPDB47521

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47521
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
AVV
Physicochemical Analysis
C13H25N3O4
RNDCEQGHILKMFPSTWY
V
287.36
6.02
0
0
3
-0
-0.03
3.400
226.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
3
C13H25N3O4
287.36
6.02
-0
-0.03
3.400
287.3543
287.1839
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
66.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Adje E. Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 5763-5769, 2010
2010
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C13H25N3O4/c1-6(2)9(15-11(17)8(5)14)12(18)16-10(7(3)4)13(19)20/h6-10H,14H2,1-5H3,(H,15,17)(H,16,18)(H,19,20)/t8-,9-,10-/m0/s1 InChIKey: BJFKXBOBGVWFCT-GUBZILKMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
66.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Adje E. Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 5763-5769, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C13H25N3O4/c1-6(2)9(15-11(17)8(5)14)12(18)16-10(7(3)4)13(19)20/h6-10H,14H2,1-5H3,(H,15,17)(H,16,18)(H,19,20)/t8-,9-,10-/m0/s1 InChIKey: BJFKXBOBGVWFCT-GUBZILKMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3