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Peptide record

TPDB47520

ACE inhibitor Phe-Gly-Gly (FGG) ACE inhibitors Antihypertensive Bitter Neuropeptide Selfassembly standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47520
ACE inhibitor Phe-Gly-Gly (FGG)
ACE inhibitors Antihypertensive Bitter Neuropeptide Selfassembly
Cardiometabolic peptides Neuroactive peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
FGG
Physicochemical Analysis
C13H17N3O4
ARNDCEQHILKMPSTWYV
G
279.30
6.02
0
0
1
-0
-1.11
0.667
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H17N3O4
279.30
6.02
-0
-1.11
0.667
279.2911
279.1215
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

28574092
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanowire Nanowires
pH: 7.3 temperature: 37 °C solvent: PBS buffer concentration: 20 mM
Selfassembly; Nanostructure=Nanowire; Nanowires; Trigger=pH: 7.3; temperature: 37 °C; solvent: PBS buffer; concentration: 20 mM
AFM, TEM
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
82.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Adje E. Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 5763-5769, 2010
2010
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)NCC(=O)O)Cc1ccccc1 InChI=1S/C13H17N3O4/c14-10(6-9-4-2-1-3-5-9)13(20)16-7-11(17)15-8-12(18)19/h1-5,10H,6-8,14H2,(H,15,17)(H,16,20)(H,18,19)/t10-/m0/s1 InChIKey: NAXPHWZXEXNDIW-JTQLQIEISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of alkaline phosphatase (EC 3.1.3.1) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
82.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Adje E. Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 5763-5769, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)NCC(=O)O)Cc1ccccc1 InChI=1S/C13H17N3O4/c14-10(6-9-4-2-1-3-5-9)13(20)16-7-11(17)15-8-12(18)19/h1-5,10H,6-8,14H2,(H,15,17)(H,16,20)(H,18,19)/t10-/m0/s1 InChIKey: NAXPHWZXEXNDIW-JTQLQIEISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of alkaline phosphatase (EC 3.1.3.1) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanowire Nanowires Trigger=pH: 7.3 temperature: 37 °C solvent: PBS buffer concentration: 20 mM
Nanowire Nanowires

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.3 temperature: 37 °C solvent: PBS buffer concentration: 20 mM
AFM, TEM
28574092
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 7.3 temperature: 37 °C solvent: PBS buffer concentration: 20 mM
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
3
28574092
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly