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Peptide record

TPDB47516

ACE inhibitor Renin inhibitor ACE inhibitors Anti-inflammatory Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47516
ACE inhibitor Renin inhibitor
ACE inhibitors Anti-inflammatory Antihypertensive
Cardiometabolic peptides Immunity and inflammation peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
GHS
Physicochemical Analysis
C11H17N5O5
ARNDCEQILKMFPTWYV
GHS
299.29
7.85
1
0
0
+0
1.10
-1.467
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C11H17N5O5
299.29
7.85
+0
1.10
-1.467
299.2825
299.1226
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.
Glycinyl-histidinyl-serine (GHS), a novel rapeseed protein-derived peptide has blood pressure-lowering effect in spontaneously hypertensive rats. J. Agric. Food Chem., 61, 8396-8402, 2013
2013
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C11H17N5O5/c12-2-9(18)15-7(1-6-3-13-5-14-6)10(19)16-8(4-17)11(20)21/h3,5,7-8,17H,1-2,4,12H2,(H,13,14)(H,15,18)(H,16,19)(H,20,21)/t7-,8-/m0/s1 InChIKey: LPCKHUXOGVNZRS-YUMQZZPRSA-N Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9472)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
hypotensive
hyp

Source & Reference

AHTPDB
He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.
Glycinyl-histidinyl-serine (GHS), a novel rapeseed protein-derived peptide has blood pressure-lowering effect in spontaneously hypertensive rats. J. Agric. Food Chem., 61, 8396-8402, 2013
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C11H17N5O5/c12-2-9(18)15-7(1-6-3-13-5-14-6)10(19)16-8(4-17)11(20)21/h3,5,7-8,17H,1-2,4,12H2,(H,13,14)(H,15,18)(H,16,19)(H,20,21)/t7-,8-/m0/s1 InChIKey: LPCKHUXOGVNZRS-YUMQZZPRSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 9473)
Evidence 3 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.
Glycinyl-histidinyl-serine (GHS), a novel rapeseed protein-derived peptide has blood pressure-lowering effect in spontaneously hypertensive rats. J. Agric. Food Chem., 61, 8396-8402, 2013
2013
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C11H17N5O5/c12-2-9(18)15-7(1-6-3-13-5-14-6)10(19)16-8(4-17)11(20)21/h3,5,7-8,17H,1-2,4,12H2,(H,13,14)(H,15,18)(H,16,19)(H,20,21)/t7-,8-/m0/s1 InChIKey: LPCKHUXOGVNZRS-YUMQZZPRSA-N Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9472)
Additional Detail Fields 1 fields
3