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Peptide record

TPDB47515

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47515
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
MAW
Physicochemical Analysis
C19H26N4O4S1
RNDCEQGHILKFPSTYV
AMW
406.50
6.02
0
0
3
-0
-2.25
0.933
33.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
1353.01
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C19H26N4O4S1
406.50
6.02
-0
-2.25
0.933
406.4992
406.1669
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
16.32 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Bougatef A., Guillochon D., Nasri M.
Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases. Food Res. Int., 43, 1136-1143, 2010
2010
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C19H26N4O4S/c1-11(22-18(25)14(20)7-8-28-2)17(24)23-16(19(26)27)9-12-10-21-15-6-4-3-5-13(12)15/h3-6,10-11,14,16,21H,7-9,20H2,1-2H3,(H,22,25)(H,23,24)(H,26,27)/t11-,14-,16-/m0/s1 InChIKey: PWPBGAJJYJJVPI-PJODQICGSA-N Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides
Evidence 2 Activity

Activity

IC50
Antihypertensive
16.32 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Bougatef A., Guillochon D., Nasri M.
Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases. Food Res. Int., 43, 1136-1143, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C19H26N4O4S/c1-11(22-18(25)14(20)7-8-28-2)17(24)23-16(19(26)27)9-12-10-21-15-6-4-3-5-13(12)15/h3-6,10-11,14,16,21H,7-9,20H2,1-2H3,(H,22,25)(H,23,24)(H,26,27)/t11-,14-,16-/m0/s1 InChIKey: PWPBGAJJYJJVPI-PJODQICGSA-N Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides
Additional Detail Fields 1 fields
3