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Peptide record

TPDB47514

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB47514
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
VIIF
Physicochemical Analysis
C26H42N4O5
ARNDCEQGHLKMPSTWY
I
490.64
6.02
0
0
4
-0
-1.68
4.000
267.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C26H42N4O5
490.64
6.02
-0
-1.68
4.000
490.6338
490.3145
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Bougatef A., Guillochon D., Nasri M.
Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases. Food Res. Int., 43, 1136-1143, 2010
2010
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@@H](C)CC)[C@@H](C)CC)C(C)C InChI=1S/C26H42N4O5/c1-7-16(5)21(24(32)28-19(26(34)35)14-18-12-10-9-11-13-18)30-25(33)22(17(6)8-2)29-23(31)20(27)15(3)4/h9-13,15-17,19-22H,7-8,14,27H2,1-6H3,(H,28,32)(H,29,31)(H,30,33)(H,34,35)/t16-,17-,19-,20-,21-,22-/m0/s1 InChIKey: KZZOSFIFCYECKN-BJYRRAHNSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
8.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Bougatef A., Guillochon D., Nasri M.
Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases. Food Res. Int., 43, 1136-1143, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@@H](C)CC)[C@@H](C)CC)C(C)C InChI=1S/C26H42N4O5/c1-7-16(5)21(24(32)28-19(26(34)35)14-18-12-10-9-11-13-18)30-25(33)22(17(6)8-2)29-23(31)20(27)15(3)4/h9-13,15-17,19-22H,7-8,14,27H2,1-6H3,(H,28,32)(H,29,31)(H,30,33)(H,34,35)/t16-,17-,19-,20-,21-,22-/m0/s1 InChIKey: KZZOSFIFCYECKN-BJYRRAHNSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4