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Peptide record

TPDB47510

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47510
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GTG
Physicochemical Analysis
C8H15N3O5
ARNDCEQHILKMFPSWYV
G
233.22
6.02
0
0
0
-0
0.16
-0.500
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C8H15N3O5
233.22
6.02
-0
0.16
-0.500
233.2212
233.1008
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
5.54 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Wang Y. K., He H. L., Chen X. L., Sun C. Y., Zhang Y. Z., Zhou B. C.
Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM. Appl. Microbiol. Biotechnol. 79, 785–791, 2008
2008
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O InChI=1S/C8H15N3O5/c1-4(12)7(11-5(13)2-9)8(16)10-3-6(14)15/h4,7,12H,2-3,9H2,1H3,(H,10,16)(H,11,13)(H,14,15)/t4-,7+/m1/s1 InChIKey: JQFILXICXLDTRR-FBCQKBJTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
5.54 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Wang Y. K., He H. L., Chen X. L., Sun C. Y., Zhang Y. Z., Zhou B. C.
Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM. Appl. Microbiol. Biotechnol. 79, 785–791, 2008
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O InChI=1S/C8H15N3O5/c1-4(12)7(11-5(13)2-9)8(16)10-3-6(14)15/h4,7,12H,2-3,9H2,1H3,(H,10,16)(H,11,13)(H,14,15)/t4-,7+/m1/s1 InChIKey: JQFILXICXLDTRR-FBCQKBJTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3