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Peptide record

TPDB47509

ACE inhibitor from soy ACE inhibitors Antihypertensive standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47509
ACE inhibitor from soy
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
DG
Physicochemical Analysis
C6H10N2O5
ARNCEQHILKMFPSTWYV
DG
190.16
3.10
0
1
0
-1
1.24
-1.950
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C6H10N2O5
190.16
3.10
-1
1.24
-1.950
190.1536
190.0587
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
12.30 µM
Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2006
book

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)NCC(=O)O InChI=1S/C6H10N2O5/c7-3(1-4(9)10)6(13)8-2-5(11)12/h3H,1-2,7H2,(H,8,13)(H,9,10)(H,11,12)/t3-/m0/s1 InChIKey: JHFNSBBHKSZXKB-VKHMYHEASA-N Another reference concerning ACE inhibition: Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713 Umami peptide according to the BIOPEP database of sensory peptides and amino acids EROP-Moscow database (ID 351) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 352)
Evidence 2 Activity

Activity

IC50
Antihypertensive
12.30 µM
Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)NCC(=O)O InChI=1S/C6H10N2O5/c7-3(1-4(9)10)6(13)8-2-5(11)12/h3H,1-2,7H2,(H,8,13)(H,9,10)(H,11,12)/t3-/m0/s1 InChIKey: JHFNSBBHKSZXKB-VKHMYHEASA-N Another reference concerning ACE inhibition: Collantes E. R., Dunn W. J., 1995, Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues. J. Med. Chem., 38, 2705-2713 Umami peptide according to the BIOPEP database of sensory peptides and amino acids EROP-Moscow database (ID 351) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 352)
Additional Detail Fields 1 fields
2