TPDB

3D PDB MODEL

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TPDB ID TPDB47506

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VVPPA

FASTA

>TPDB47506|ACE inhibitors;Antihypertensive;Neuropeptide|length=5
VVPPA

Formula C23H39N5O6

Absent Amino Acids RNDCEQGHILKMFSTWY

Common Amino Acids PV

Mass 481.59

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 0.87

Hydrophobicity 1.400

Aliphatic Index 136.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

5

Formula

C23H39N5O6

Mass

481.59

PI

6.02

Net Charge

-0

Boman Index

0.87

Hydrophobicity

1.400

Chemical_Mass

481.5841

Monoisotopic_Mass

481.2891

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 79.50 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Suetsuna K., Chen J.-R.

Title

Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnol., 3, 305–309, 2001

Year 2001

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C23H39N5O6/c1-12(2)17(24)20(30)26-18(13(3)4)22(32)28-11-7-9-16(28)21(31)27-10-6-8-15(27)19(29)25-14(5)23(33)34/h12-18H,6-11,24H2,1-5H3,(H,25,29)(H,26,30)(H,33,34)/t14-,15-,16-,17-,18-/m0/s1 InChIKey: YDURAHOGQWSWPJ-ATIWLJMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 79.50 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Suetsuna K., Chen J.-R.

Title

Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnol., 3, 305–309, 2001

Year 2001

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C23H39N5O6/c1-12(2)17(24)20(30)26-18(13(3)4)22(32)28-11-7-9-16(28)21(31)27-10-6-8-15(27)19(29)25-14(5)23(33)34/h12-18H,6-11,24H2,1-5H3,(H,25,29)(H,26,30)(H,33,34)/t14-,15-,16-,17-,18-/m0/s1 InChIKey: YDURAHOGQWSWPJ-ATIWLJMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5