TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB47502

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

IVVE

FASTA

>TPDB47502|ACE inhibitors;Antihypertensive|length=4
IVVE

Formula C21H38N4O7

Absent Amino Acids ARNDCQGHLKMFPSTWY

Common Amino Acids V

Mass 458.56

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.85

Hydrophobicity 2.350

Aliphatic Index 242.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

4

Formula

C21H38N4O7

Mass

458.56

PI

3.29

Net Charge

-1

Boman Index

1.85

Hydrophobicity

2.350

Chemical_Mass

458.5475

Monoisotopic_Mass

458.2731

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 315.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Suetsuna K., Chen J.-R.

Title

Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnol., 3, 305–309, 2001

Year 2001

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C21H38N4O7/c1-7-12(6)15(22)18(28)24-17(11(4)5)20(30)25-16(10(2)3)19(29)23-13(21(31)32)8-9-14(26)27/h10-13,15-17H,7-9,22H2,1-6H3,(H,23,29)(H,24,28)(H,25,30)(H,26,27)(H,31,32)/t12-,13-,15-,16-,17-/m0/s1 InChIKey: VLVIDBIIZPQZIW-PTTAZLHSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 315.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Suetsuna K., Chen J.-R.

Title

Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnol., 3, 305–309, 2001

Year 2001

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C21H38N4O7/c1-7-12(6)15(22)18(28)24-17(11(4)5)20(30)25-16(10(2)3)19(29)23-13(21(31)32)8-9-14(26)27/h10-13,15-17H,7-9,22H2,1-6H3,(H,23,29)(H,24,28)(H,25,30)(H,26,27)(H,31,32)/t12-,13-,15-,16-,17-/m0/s1 InChIKey: VLVIDBIIZPQZIW-PTTAZLHSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

4