TPDB

3D PDB MODEL

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TPDB ID TPDB47501

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

YNKL

FASTA

>TPDB47501|ACE inhibitors;Antihypertensive|length=4
YNKL

Formula C25H40N6O7

Absent Amino Acids ARDCEQGHIMFPSTWV

Common Amino Acids NLKY

Mass 536.63

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index -0.09

Hydrophobicity -1.225

Aliphatic Index 97.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 277.66

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

4

Formula

C25H40N6O7

Mass

536.63

PI

9.74

Net Charge

+1

Boman Index

-0.09

Hydrophobicity

-1.225

Chemical_Mass

536.6195

Monoisotopic_Mass

536.2949

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 21.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Suetsuna K., Nakano T.

Title

Identification of an antihypertensive peptide from a peptic digest of wakame (Undaria pinnatifida). J. Nutr. Biochem. 11, 450-454, 2000

Year 2000

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C25H40N6O7/c1-14(2)11-20(25(37)38)31-23(35)18(5-3-4-10-26)29-24(36)19(13-21(28)33)30-22(34)17(27)12-15-6-8-16(32)9-7-15/h6-9,14,17-20,32H,3-5,10-13,26-27H2,1-2H3,(H2,28,33)(H,29,36)(H,30,34)(H,31,35)(H,37,38)/t17-,18-,19-,20-/m0/s1 InChIKey: FSMAPTIYUISZHW-MUGJNUQGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 21.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Suetsuna K., Nakano T.

Title

Identification of an antihypertensive peptide from a peptic digest of wakame (Undaria pinnatifida). J. Nutr. Biochem. 11, 450-454, 2000

Year 2000

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C25H40N6O7/c1-14(2)11-20(25(37)38)31-23(35)18(5-3-4-10-26)29-24(36)19(13-21(28)33)30-22(34)17(27)12-15-6-8-16(32)9-7-15/h6-9,14,17-20,32H,3-5,10-13,26-27H2,1-2H3,(H2,28,33)(H,29,36)(H,30,34)(H,31,35)(H,37,38)/t17-,18-,19-,20-/m0/s1 InChIKey: FSMAPTIYUISZHW-MUGJNUQGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

4