TPDB

3D PDB MODEL

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TPDB ID TPDB47495

Peptide_Name

ACE inhibitor from dried bonito

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LKPNM

FASTA

>TPDB47495|ACE inhibitors;Antihypertensive|length=5
LKPNM

Formula C26H47N7O7S1

Absent Amino Acids ARDCEQGHIFSTWYV

Common Amino Acids NLKMP

Mass 601.76

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.07

Hydrophobicity -0.660

Aliphatic Index 78.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C26H47N7O7S1

Mass

601.76

PI

10.10

Net Charge

+1

Boman Index

1.07

Hydrophobicity

-0.660

Chemical_Mass

601.7583

Monoisotopic_Mass

601.3247

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 2.40 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Yokoyama K., Chiba H., Yoshikawa M.

Title

Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992

Year 1992

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C26H47N7O7S/c1-15(2)13-16(28)22(35)30-17(7-4-5-10-27)25(38)33-11-6-8-20(33)24(37)32-19(14-21(29)34)23(36)31-18(26(39)40)9-12-41-3/h15-20H,4-14,27-28H2,1-3H3,(H2,29,34)(H,30,35)(H,31,36)(H,32,37)(H,39,40)/t16-,17-,18-,19-,20-/m0/s1 InChIKey: UHUTUNQDWZAIEF-HVTWWXFQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 2.40 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Yokoyama K., Chiba H., Yoshikawa M.

Title

Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem., 56, 1541-1545, 1992

Year 1992

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C26H47N7O7S/c1-15(2)13-16(28)22(35)30-17(7-4-5-10-27)25(38)33-11-6-8-20(33)24(37)32-19(14-21(29)34)23(36)31-18(26(39)40)9-12-41-3/h15-20H,4-14,27-28H2,1-3H3,(H2,29,34)(H,30,35)(H,31,36)(H,32,37)(H,39,40)/t16-,17-,18-,19-,20-/m0/s1 InChIKey: UHUTUNQDWZAIEF-HVTWWXFQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5