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Peptide record

TPDB47492

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB47492
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
GDAP
Physicochemical Analysis
C14H22N4O7
RNCEQHILKMFSTWYV
ADGP
358.35
3.10
0
1
1
-1
1.52
-0.925
25.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C14H22N4O7
358.35
3.10
-1
1.52
-0.925
358.3462
358.1483
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
22.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Adjé E.Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 3840-3846, 2010
2010
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(O)=O)NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C14H22N4O7/c1-7(13(23)18-4-2-3-9(18)14(24)25)16-12(22)8(5-11(20)21)17-10(19)6-15/h7-9H,2-6,15H2,1H3,(H,16,22)(H,17,19)(H,20,21)(H,24,25)/t7-,8-,9-/m0/s1 InChIKey=RKMSJZDTSGNVKS-CIUDSAMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
22.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Adjé E.Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 3840-3846, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(O)=O)NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C14H22N4O7/c1-7(13(23)18-4-2-3-9(18)14(24)25)16-12(22)8(5-11(20)21)17-10(19)6-15/h7-9H,2-6,15H2,1H3,(H,16,22)(H,17,19)(H,20,21)(H,24,25)/t7-,8-,9-/m0/s1 InChIKey=RKMSJZDTSGNVKS-CIUDSAMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
4