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Peptide record

TPDB47491

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB47491
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
AHSY
Physicochemical Analysis
C21H28N6O7
RNDCEQGILKMFPTWV
AHSY
476.49
7.77
1
0
2
+0
-0.02
-0.875
25.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
312.70
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C21H28N6O7
476.49
7.77
+0
-0.02
-0.875
476.4819
476.2013
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
11.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Balti R., Nedjar-Arroume N., Adjé E.Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 3840-3846, 2010
2010
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C21H28N6O7/c1-11(22)18(30)25-15(7-13-8-23-10-24-13)19(31)27-17(9-28)20(32)26-16(21(33)34)6-12-2-4-14(29)5-3-12/h2-5,8,10-11,15-17,28-29H,6-7,9,22H2,1H3,(H,23,24)(H,25,30)(H,26,32)(H,27,31)(H,33,34)/t11-,15-,16-,17-/m0/s1 InChIKey=BBJPQNGNBLXKQS-SPOWBLRKSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
11.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Balti R., Nedjar-Arroume N., Adjé E.Y., Guillochon D., Nasri M.
Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 58, 3840-3846, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C21H28N6O7/c1-11(22)18(30)25-15(7-13-8-23-10-24-13)19(31)27-17(9-28)20(32)26-16(21(33)34)6-12-2-4-14(29)5-3-12/h2-5,8,10-11,15-17,28-29H,6-7,9,22H2,1H3,(H,23,24)(H,25,30)(H,26,32)(H,27,31)(H,33,34)/t11-,15-,16-,17-/m0/s1 InChIKey=BBJPQNGNBLXKQS-SPOWBLRKSA-N
Additional Detail Fields 1 fields
4