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Peptide record

TPDB47451

ACE inhibitor ACE inhibitors Antihypertensive modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB47451
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB
modified_plain
Yes
A 11-aa modified multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.
Modified, details unspecified
Sequence
JGLPPGPPIPP
Physicochemical Analysis
C46H72N10O11
ARNDCEQHKMFSTWYV
P
941.14
6.02
0
0
2
-0
1.85
-0.191
70.91
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
1
L
0
K
0
M
0
F
6
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 6 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C46H72N10O11
941.14
6.02
-0
1.85
-0.191
941.1214
940.5365
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
4.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kato H., Suzuki T.
Bradykinin-potentiating peptides from venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and amino acid sequences of two of them, potentiators B and C. Biochemistry, 10, 972-980, 1971
1971
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C46H72N10O11/c1-5-28(4)38(45(65)55-22-10-16-34(55)44(64)56-23-11-17-35(56)46(66)67)50-40(60)31-13-7-20-53(31)42(62)32-14-8-18-51(32)37(58)26-48-39(59)30-12-6-19-52(30)43(63)33-15-9-21-54(33)41(61)29(24-27(2)3)49-36(57)25-47/h27-35,38H,5-26,47H2,1-4H3,(H,48,59)(H,49,57)(H,50,60)(H,66,67)/t28-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey=UALXDFDEASGIQC-BMBRTWATSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
4.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kato H., Suzuki T.
Bradykinin-potentiating peptides from venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and amino acid sequences of two of them, potentiators B and C. Biochemistry, 10, 972-980, 1971
1971
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C46H72N10O11/c1-5-28(4)38(45(65)55-22-10-16-34(55)44(64)56-23-11-17-35(56)46(66)67)50-40(60)31-13-7-20-53(31)42(62)32-14-8-18-51(32)37(58)26-48-39(59)30-12-6-19-52(30)43(63)33-15-9-21-54(33)41(61)29(24-27(2)3)49-36(57)25-47/h27-35,38H,5-26,47H2,1-4H3,(H,48,59)(H,49,57)(H,50,60)(H,66,67)/t28-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey=UALXDFDEASGIQC-BMBRTWATSA-N
Additional Detail Fields 1 fields
11