TPDB

3D PDB MODEL

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TPDB ID TPDB47426

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

LGPLGHQ

FASTA

>TPDB47426|ACE inhibitors;Antihypertensive|length=7
LGPLGHQ

Formula C32H52N10O9

Absent Amino Acids ARNDCEIKMFSTWYV

Common Amino Acids GL

Mass 720.83

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 0.89

Hydrophobicity -0.214

Aliphatic Index 111.43

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

2

G

1

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C32H52N10O9

Mass

720.83

PI

7.85

Net Charge

+0

Boman Index

0.89

Hydrophobicity

-0.214

Chemical_Mass

720.8148

Monoisotopic_Mass

720.3907

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.22 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ngo D.H., Ryu B., Kim S.K.

Title

Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation. Food Chemistry 143, 246-255, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@@]([H])(N)CC(C)C)C=O InChI=1S/C32H52N10O8/c1-18(2)10-22(33)29(47)37-15-28(46)42-9-5-6-25(42)32(50)41-23(11-19(3)4)30(48)36-14-27(45)40-24(12-21-13-35-17-38-21)31(49)39-20(16-43)7-8-26(34)44/h13,16-20,22-25H,5-12,14-15,33H2,1-4H3,(H2,34,44)(H,35,38)(H,36,48)(H,37,47)(H,39,49)(H,40,45)(H,41,50)/t20-,22-,23-,24-,25-/m0/s1 InChIKey=XUXCSDXUZTVENZ-NPJMLQJUSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.22 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Ngo D.H., Ryu B., Kim S.K.

Title

Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation. Food Chemistry 143, 246-255, 2014

Year 2014

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@@]([H])(N)CC(C)C)C=O InChI=1S/C32H52N10O8/c1-18(2)10-22(33)29(47)37-15-28(46)42-9-5-6-25(42)32(50)41-23(11-19(3)4)30(48)36-14-27(45)40-24(12-21-13-35-17-38-21)31(49)39-20(16-43)7-8-26(34)44/h13,16-20,22-25H,5-12,14-15,33H2,1-4H3,(H2,34,44)(H,35,38)(H,36,48)(H,37,47)(H,39,49)(H,40,45)(H,41,50)/t20-,22-,23-,24-,25-/m0/s1 InChIKey=XUXCSDXUZTVENZ-NPJMLQJUSA-N

Number_of_Residues

7