TPDB

3D PDB MODEL

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TPDB ID TPDB47425

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

MVGSAPGVL

FASTA

>TPDB47425|ACE inhibitors;Antihypertensive|length=9
MVGSAPGVL

Formula C36H63N9O11S1

Absent Amino Acids RNDCEQHIKFTWY

Common Amino Acids GV

Mass 830.01

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -0.22

Hydrophobicity 1.411

Aliphatic Index 118.89

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

0

I

1

L

0

K

1

M

0

F

1

P

1

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2

Length

9

Formula

C36H63N9O11S1

Mass

830.01

PI

6.02

Net Charge

-0

Boman Index

-0.22

Hydrophobicity

1.411

Chemical_Mass

830.0027

Monoisotopic_Mass

829.4353

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 3.09 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ngo D.H., Ryu B., Kim S.K.

Title

Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation. Food Chemistry 143, 246-255, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C36H63N9O11S/c1-18(2)14-23(36(55)56)42-34(53)29(20(5)6)43-27(48)16-38-32(51)25-10-9-12-45(25)35(54)21(7)40-31(50)24(17-46)41-26(47)15-39-33(52)28(19(3)4)44-30(49)22(37)11-13-57-8/h18-25,28-29,46H,9-17,37H2,1-8H3,(H,38,51)(H,39,52)(H,40,50)(H,41,47)(H,42,53)(H,43,48)(H,44,49)(H,55,56)/t21-,22-,23-,24-,25-,28-,29-/m0/s1 InChIKey: LQEXMYMFFWFJDO-DAOOESDTSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 3.09 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Ngo D.H., Ryu B., Kim S.K.

Title

Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation. Food Chemistry 143, 246-255, 2014

Year 2014

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C36H63N9O11S/c1-18(2)14-23(36(55)56)42-34(53)29(20(5)6)43-27(48)16-38-32(51)25-10-9-12-45(25)35(54)21(7)40-31(50)24(17-46)41-26(47)15-39-33(52)28(19(3)4)44-30(49)22(37)11-13-57-8/h18-25,28-29,46H,9-17,37H2,1-8H3,(H,38,51)(H,39,52)(H,40,50)(H,41,47)(H,42,53)(H,43,48)(H,44,49)(H,55,56)/t21-,22-,23-,24-,25-,28-,29-/m0/s1 InChIKey: LQEXMYMFFWFJDO-DAOOESDTSA-N

Number_of_Residues

9