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Peptide record

TPDB47424

ACE inhibitor from beta-CN (202-209) ACE inhibitors Antihypertensive Bitter standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47424
ACE inhibitor from beta-CN (202-209)
ACE inhibitors Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
pep-lab Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Bitter) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
RGPFPIIV
Physicochemical Analysis
C44H71N11O9
ANDCEQHLKMSTWY
IP
898.12
11.05
1
0
4
+1
0.04
0.987
133.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
8
C44H71N11O9
898.12
11.05
+1
0.04
0.987
898.1000
897.5420
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Hayes M., Stanton C., Fitzgerald G.F., Ross R.P.
Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions. Biotechnol. J., 2 (2007), 435–449.
2007
Journal

Other

8
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C44H71N11O9/c1-7-26(5)35(41(61)53-36(27(6)8-2)40(60)51-34(25(3)4)43(63)64)52-39(59)32-19-14-22-55(32)42(62)30(23-28-15-10-9-11-16-28)50-38(58)31-18-13-21-54(31)33(56)24-49-37(57)29(45)17-12-20-48-44(46)47/h9-11,15-16,25-27,29-32,34-36H,7-8,12-14,17-24,45H2,1-6H3,(H,49,57)(H,50,58)(H,51,60)(H,52,59)(H,53,61)(H,63,64)(H4,46,47,48)/t26-,27-,29-,30-,31+,32+,34-,35-,36-/m0/s1 InChIKey: CWVNDSADIDMCFJ-OGTKHFNDSA-N Bitter peptide according to the BIOPEP database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hayes M., Stanton C., Fitzgerald G.F., Ross R.P.
Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions. Biotechnol. J., 2 (2007), 435–449.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C44H71N11O9/c1-7-26(5)35(41(61)53-36(27(6)8-2)40(60)51-34(25(3)4)43(63)64)52-39(59)32-19-14-22-55(32)42(62)30(23-28-15-10-9-11-16-28)50-38(58)31-18-13-21-54(31)33(56)24-49-37(57)29(45)17-12-20-48-44(46)47/h9-11,15-16,25-27,29-32,34-36H,7-8,12-14,17-24,45H2,1-6H3,(H,49,57)(H,50,58)(H,51,60)(H,52,59)(H,53,61)(H,63,64)(H4,46,47,48)/t26-,27-,29-,30-,31+,32+,34-,35-,36-/m0/s1 InChIKey: CWVNDSADIDMCFJ-OGTKHFNDSA-N Bitter peptide according to the BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
8