TPDB

3D PDB MODEL

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TPDB ID TPDB47420

Peptide_Name

ACE inhibitor from b-CN (47-59) mouse

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

VHSSIQSQPQAFT

FASTA

>TPDB47420|ACE inhibitors;Antihypertensive|length=13
VHSSIQSQPQAFT

Formula C62H96N18O21

Absent Amino Acids RNDCEGLKMWY

Common Amino Acids QS

Mass 1429.55

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index 2.14

Hydrophobicity -0.392

Aliphatic Index 60.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 7

number

1

A

0

R

0

N

0

D

0

C

0

E

3

Q

0

G

1

H

1

I

0

L

0

K

0

M

1

F

1

P

3

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 1 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 1

Length

13

Formula

C62H96N18O21

Mass

1429.55

PI

7.85

Net Charge

+0

Boman Index

2.14

Hydrophobicity

-0.392

Chemical_Mass

1429.5298

Monoisotopic_Mass

1428.6975

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1001.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Meisel H., Walsh D. J., Murray B., FitzGerald R. J.

Title

ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.

Year 2006

Literature Source book

Other

Number of Residues 13

Additional Info EC50>1000

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 1001.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Meisel H., Walsh D. J., Murray B., FitzGerald R. J.

Title

ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.

Year 2006

Literature Source book

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 13

Additional Info EC50>1000

Number_of_Residues

13