TPDB

3D PDB MODEL

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TPDB ID TPDB47416

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

YGLVAGTW

FASTA

>TPDB47416|ACE inhibitors;Antihypertensive|length=8
YGLVAGTW

Formula C42H59N9O11

Absent Amino Acids RNDCEQHIKMFPS

Common Amino Acids G

Mass 865.98

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 5

Net Charge -0

Boman Index -3.29

Hydrophobicity 0.762

Aliphatic Index 97.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 807.17

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

1

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 1

Length

8

Formula

C42H59N9O11

Mass

865.98

PI

5.94

Net Charge

-0

Boman Index

-3.29

Hydrophobicity

0.762

Chemical_Mass

865.9692

Monoisotopic_Mass

865.4320

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)[C@@]([H])(C)O InChI=1S/C42H59N9O11/c1-21(2)15-31(48-33(54)19-46-38(57)29(43)16-25-11-13-27(53)14-12-25)39(58)51-35(22(3)4)40(59)47-23(5)37(56)45-20-34(55)50-36(24(6)52)41(60)49-32(42(61)62)17-26-18-44-30-10-8-7-9-28(26)30/h7-14,18,21-24,29,31-32,35-36,44,52-53H,15-17,19-20,43H2,1-6H3,(H,45,56)(H,46,57)(H,47,59)(H,48,54)(H,49,60)(H,50,55)(H,51,58)(H,61,62)/t23-,24+,29-,31-,32-,35-,36-/m0/s1 InChIKey=VLWQCXIPCPRHRM-JUKKNPBESA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@]([H])(C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)[C@@]([H])(C)O InChI=1S/C42H59N9O11/c1-21(2)15-31(48-33(54)19-46-38(57)29(43)16-25-11-13-27(53)14-12-25)39(58)51-35(22(3)4)40(59)47-23(5)37(56)45-20-34(55)50-36(24(6)52)41(60)49-32(42(61)62)17-26-18-44-30-10-8-7-9-28(26)30/h7-14,18,21-24,29,31-32,35-36,44,52-53H,15-17,19-20,43H2,1-6H3,(H,45,56)(H,46,57)(H,47,59)(H,48,54)(H,49,60)(H,50,55)(H,51,58)(H,61,62)/t23-,24+,29-,31-,32-,35-,36-/m0/s1 InChIKey=VLWQCXIPCPRHRM-JUKKNPBESA-N

Number_of_Residues

8