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Peptide record

TPDB47415

ACE inhibitor ACE inhibitors Antihypertensive standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB47415
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 13-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FFVAPFPFEVFGK
Physicochemical Analysis
C81H106N14O16
RNDCQHILMSTWY
F
1531.82
6.94
1
1
8
-0
-1.76
1.015
52.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
5
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 5 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
13
C81H106N14O16
1531.82
6.94
-0
-1.76
1.015
1531.7883
1530.7886
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
77.00 µM
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus.Agric.Biol.Chem.49(5),1405-1409(1985)
1985
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C81H106N14O16/c1-49(2)68(93-74(103)62(46-55-31-17-9-18-32-55)88-70(99)57(83)43-52-25-11-6-12-26-52)77(106)85-51(5)79(108)94-41-23-36-64(94)76(105)91-63(47-56-33-19-10-20-34-56)80(109)95-42-24-37-65(95)75(104)89-61(45-54-29-15-8-16-30-54)73(102)87-58(38-39-67(97)98)72(101)92-69(50(3)4)78(107)90-60(44-53-27-13-7-14-28-53)71(100)84-48-66(96)86-59(81(110)111)35-21-22-40-82/h6-20,25-34,49-51,57-65,68-69H,21-24,35-48,82-83H2,1-5H3,(H,84,100)(H,85,106)(H,86,96)(H,87,102)(H,88,99)(H,89,104)(H,90,107)(H,91,105)(H,92,101)(H,93,103)(H,97,98)(H,110,111)/t51-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 InChIKey=IFLAAXRMZSXTGW-FOPHCWOJSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
77.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus.Agric.Biol.Chem.49(5),1405-1409(1985)
1985
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C81H106N14O16/c1-49(2)68(93-74(103)62(46-55-31-17-9-18-32-55)88-70(99)57(83)43-52-25-11-6-12-26-52)77(106)85-51(5)79(108)94-41-23-36-64(94)76(105)91-63(47-56-33-19-10-20-34-56)80(109)95-42-24-37-65(95)75(104)89-61(45-54-29-15-8-16-30-54)73(102)87-58(38-39-67(97)98)72(101)92-69(50(3)4)78(107)90-60(44-53-27-13-7-14-28-53)71(100)84-48-66(96)86-59(81(110)111)35-21-22-40-82/h6-20,25-34,49-51,57-65,68-69H,21-24,35-48,82-83H2,1-5H3,(H,84,100)(H,85,106)(H,86,96)(H,87,102)(H,88,99)(H,89,104)(H,90,107)(H,91,105)(H,92,101)(H,93,103)(H,97,98)(H,110,111)/t51-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 InChIKey=IFLAAXRMZSXTGW-FOPHCWOJSA-N
Additional Detail Fields 1 fields
13