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Peptide record

TPDB47414

ACE inhibitors derived from yeast GADPH ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47414
ACE inhibitors derived from yeast GADPH
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GKKIATYQER
Physicochemical Analysis
C52H88N16O16
NDCHLMFPSWV
K
1193.37
10.19
3
1
3
+2
4.12
-1.540
49.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
124.86
3
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C52H88N16O16
1193.37
10.19
+2
4.12
-1.540
1193.3492
1192.6544
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohama Y., Nagase Y., Oka H., Nakagawa T., Teramoto T., Murayama N., Tsujibo H.,
Production of angiotensin-converting enzyme inhibitors from baker's yeasts Glyceraldehyde-3-phosphate Dehydrogenase. J. Pharmacobio-Dyn. 13, 766-771
1990
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C52H88N16O16/c1-5-27(2)41(67-47(79)33(12-7-9-23-54)62-44(76)32(11-6-8-22-53)61-39(72)26-55)49(81)60-28(3)43(75)68-42(29(4)69)50(82)66-37(25-30-14-16-31(70)17-15-30)48(80)64-34(18-20-38(56)71)45(77)63-35(19-21-40(73)74)46(78)65-36(51(83)84)13-10-24-59-52(57)58/h14-17,27-29,32-37,41-42,69-70H,5-13,18-26,53-55H2,1-4H3,(H2,56,71)(H,60,81)(H,61,72)(H,62,76)(H,63,77)(H,64,80)(H,65,78)(H,66,82)(H,67,79)(H,68,75)(H,73,74)(H,83,84)(H4,57,58,59)/t27-,28-,29+,32-,33-,34-,35-,36-,37-,41-,42-/m0/s1 InChIKey=OSXRNCSRDFEOTA-PBEFRTBXSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohama Y., Nagase Y., Oka H., Nakagawa T., Teramoto T., Murayama N., Tsujibo H.,
Production of angiotensin-converting enzyme inhibitors from baker's yeasts Glyceraldehyde-3-phosphate Dehydrogenase. J. Pharmacobio-Dyn. 13, 766-771
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCCCN)NC(=O)CN)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C52H88N16O16/c1-5-27(2)41(67-47(79)33(12-7-9-23-54)62-44(76)32(11-6-8-22-53)61-39(72)26-55)49(81)60-28(3)43(75)68-42(29(4)69)50(82)66-37(25-30-14-16-31(70)17-15-30)48(80)64-34(18-20-38(56)71)45(77)63-35(19-21-40(73)74)46(78)65-36(51(83)84)13-10-24-59-52(57)58/h14-17,27-29,32-37,41-42,69-70H,5-13,18-26,53-55H2,1-4H3,(H2,56,71)(H,60,81)(H,61,72)(H,62,76)(H,63,77)(H,64,80)(H,65,78)(H,66,82)(H,67,79)(H,68,75)(H,73,74)(H,83,84)(H4,57,58,59)/t27-,28-,29+,32-,33-,34-,35-,36-,37-,41-,42-/m0/s1 InChIKey=OSXRNCSRDFEOTA-PBEFRTBXSA-N
Additional Detail Fields 1 fields
10