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Peptide record

TPDB47412

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47412
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PSKIKWGD
Physicochemical Analysis
C43H67N11O12
ARNCEQHLMFTYV
K
930.07
9.88
2
1
2
+1
1.64
-1.313
48.75
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
591.35
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
2
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C43H67N11O12
930.07
9.88
+1
1.64
-1.313
930.0559
929.4955
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
68.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohama Y., Oka H., Yamamoto K., Teramoto T., Okabe M., Mimura T., Nagase Y., Chiba Y., Fujita T.
Induction of angiotensin-converting enzyme inhibitory activity by acid-limited proteolysis of glyceraldehyde-3-phosphate dehydrogenase. Biochem. Biophys. Res. Commun., 161, 456-460
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CO)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O InChI=1S/C43H67N11O12/c1-3-24(2)36(54-40(62)30(14-7-9-17-45)50-41(63)33(23-55)53-38(60)28-15-10-18-46-28)42(64)51-29(13-6-8-16-44)39(61)52-31(19-25-21-47-27-12-5-4-11-26(25)27)37(59)48-22-34(56)49-32(43(65)66)20-35(57)58/h4-5,11-12,21,24,28-33,36,46-47,55H,3,6-10,13-20,22-23,44-45H2,1-2H3,(H,48,59)(H,49,56)(H,50,63)(H,51,64)(H,52,61)(H,53,60)(H,54,62)(H,57,58)(H,65,66)/t24-,28-,29-,30-,31-,32-,33-,36-/m0/s1 InChIKey=YXMZWRFFDBNFRU-BVXGOKOCSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
68.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohama Y., Oka H., Yamamoto K., Teramoto T., Okabe M., Mimura T., Nagase Y., Chiba Y., Fujita T.
Induction of angiotensin-converting enzyme inhibitory activity by acid-limited proteolysis of glyceraldehyde-3-phosphate dehydrogenase. Biochem. Biophys. Res. Commun., 161, 456-460
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CO)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@]([H])(CC(O)=O)C(O)=O InChI=1S/C43H67N11O12/c1-3-24(2)36(54-40(62)30(14-7-9-17-45)50-41(63)33(23-55)53-38(60)28-15-10-18-46-28)42(64)51-29(13-6-8-16-44)39(61)52-31(19-25-21-47-27-12-5-4-11-26(25)27)37(59)48-22-34(56)49-32(43(65)66)20-35(57)58/h4-5,11-12,21,24,28-33,36,46-47,55H,3,6-10,13-20,22-23,44-45H2,1-2H3,(H,48,59)(H,49,56)(H,50,63)(H,51,64)(H,52,61)(H,53,60)(H,54,62)(H,57,58)(H,65,66)/t24-,28-,29-,30-,31-,32-,33-,36-/m0/s1 InChIKey=YXMZWRFFDBNFRU-BVXGOKOCSA-N
Additional Detail Fields 1 fields
8