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Peptide record

TPDB47411

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB47411
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
YPWTQR
Physicochemical Analysis
C40H55N11O10
ANDCEGHILKMFSV
RQPTWY
849.94
9.88
1
0
2
+1
-0.81
-2.083
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
822.41
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
6
C40H55N11O10
849.94
9.88
+1
-0.81
-2.083
849.9302
849.4121
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lantz I., Glämsta E.-L., Tälback L., Nyberg F.
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41, 1991
1991
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=C(C=C4)O)N)O InChI=1S/C40H55N11O10/c1-21(52)33(37(58)47-28(14-15-32(42)54)34(55)48-29(39(60)61)8-4-16-45-40(43)44)50-35(56)30(19-23-20-46-27-7-3-2-6-25(23)27)49-36(57)31-9-5-17-51(31)38(59)26(41)18-22-10-12-24(53)13-11-22/h2-3,6-7,10-13,20-21,26,28-31,33,46,52-53H,4-5,8-9,14-19,41H2,1H3,(H2,42,54)(H,47,58)(H,48,55)(H,49,57)(H,50,56)(H,60,61)(H4,43,44,45)/t21-,26+,28+,29+,30+,31+,33+/m1/s1 InChIKey=SHLDOWBZATZTBQ-KUTFLANJSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3080), the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Lantz I., Glämsta E.-L., Tälback L., Nyberg F.
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin-converting enzyme activity. FEBS Lett., 287, 39-41, 1991
1991
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=C(C=C4)O)N)O InChI=1S/C40H55N11O10/c1-21(52)33(37(58)47-28(14-15-32(42)54)34(55)48-29(39(60)61)8-4-16-45-40(43)44)50-35(56)30(19-23-20-46-27-7-3-2-6-25(23)27)49-36(57)31-9-5-17-51(31)38(59)26(41)18-22-10-12-24(53)13-11-22/h2-3,6-7,10-13,20-21,26,28-31,33,46,52-53H,4-5,8-9,14-19,41H2,1H3,(H2,42,54)(H,47,58)(H,48,55)(H,49,57)(H,50,56)(H,60,61)(H4,43,44,45)/t21-,26+,28+,29+,30+,31+,33+/m1/s1 InChIKey=SHLDOWBZATZTBQ-KUTFLANJSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3080), the EROP-Moscow database
Additional Detail Fields 1 fields
6