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Peptide record

TPDB47410

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47410
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FPFEVFGK
Physicochemical Analysis
C50H67N9O11
ARNDCQHILMSTWY
F
970.14
6.94
1
1
4
-0
0.15
0.400
36.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
8
C50H67N9O11
970.14
6.94
-0
0.15
0.400
970.1180
969.4944
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agric Biol Chem 49, 1405-1409
1985
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C50H67N9O11/c1-31(2)43(48(67)57-38(28-33-17-8-4-9-18-33)44(63)53-30-41(60)54-37(50(69)70)21-12-13-25-51)58-45(64)36(23-24-42(61)62)55-46(65)39(29-34-19-10-5-11-20-34)56-47(66)40-22-14-26-59(40)49(68)35(52)27-32-15-6-3-7-16-32/h3-11,15-20,31,35-40,43H,12-14,21-30,51-52H2,1-2H3,(H,53,63)(H,54,60)(H,55,65)(H,56,66)(H,57,67)(H,58,64)(H,61,62)(H,69,70)/t35-,36-,37-,38-,39-,40-,43-/m0/s1 InChIKey=RHGGHUOJGJKAPD-GSCWUVFKS
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agric Biol Chem 49, 1405-1409
1985
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C50H67N9O11/c1-31(2)43(48(67)57-38(28-33-17-8-4-9-18-33)44(63)53-30-41(60)54-37(50(69)70)21-12-13-25-51)58-45(64)36(23-24-42(61)62)55-46(65)39(29-34-19-10-5-11-20-34)56-47(66)40-22-14-26-59(40)49(68)35(52)27-32-15-6-3-7-16-32/h3-11,15-20,31,35-40,43H,12-14,21-30,51-52H2,1-2H3,(H,53,63)(H,54,60)(H,55,65)(H,56,66)(H,57,67)(H,58,64)(H,61,62)(H,69,70)/t35-,36-,37-,38-,39-,40-,43-/m0/s1 InChIKey=RHGGHUOJGJKAPD-GSCWUVFKS
Additional Detail Fields 1 fields
8