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Peptide record

TPDB47400

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47400
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GYALPHA
Physicochemical Analysis
C34H49N9O9
RNDCEQIKMFSTWV
A
727.82
7.77
1
0
4
+0
-0.42
0.129
84.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
204.72
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C34H49N9O9
727.82
7.77
+0
-0.42
0.129
727.8058
727.3642
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
27.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Wako Y., Ishikawa S., Muramoto K.
Angiotensin I-converting enzyme inhibitors in autolysates of squid liver and mantle muscle. Biosci. Biotech. Biochem., 60, 1353-1355, 1996
1996
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC1=CN=CN1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)CN)C(O)=O InChI=1S/C34H49N9O9/c1-18(2)12-26(42-29(46)19(3)38-30(47)24(40-28(45)15-35)13-21-7-9-23(44)10-8-21)33(50)43-11-5-6-27(43)32(49)41-25(14-22-16-36-17-37-22)31(48)39-20(4)34(51)52/h7-10,16-20,24-27,44H,5-6,11-15,35H2,1-4H3,(H,36,37)(H,38,47)(H,39,48)(H,40,45)(H,41,49)(H,42,46)(H,51,52)/t19-,20-,24-,25-,26-,27-/m0/s1 InChIKey=UBJDWWUQPGDMRJ-OHZUUNIUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
27.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wako Y., Ishikawa S., Muramoto K.
Angiotensin I-converting enzyme inhibitors in autolysates of squid liver and mantle muscle. Biosci. Biotech. Biochem., 60, 1353-1355, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC1=CN=CN1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)CN)C(O)=O InChI=1S/C34H49N9O9/c1-18(2)12-26(42-29(46)19(3)38-30(47)24(40-28(45)15-35)13-21-7-9-23(44)10-8-21)33(50)43-11-5-6-27(43)32(49)41-25(14-22-16-36-17-37-22)31(48)39-20(4)34(51)52/h7-10,16-20,24-27,44H,5-6,11-15,35H2,1-4H3,(H,36,37)(H,38,47)(H,39,48)(H,40,45)(H,41,49)(H,42,46)(H,51,52)/t19-,20-,24-,25-,26-,27-/m0/s1 InChIKey=UBJDWWUQPGDMRJ-OHZUUNIUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
7