TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB47393

Peptide_Name

DPPIV inhibitor

Activity

Antidiabetic Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Antidiabetic and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

VAPEEHPT

FASTA

>TPDB47393|Antidiabetic;Antihypertensive|length=8
VAPEEHPT

Formula C38H58N10O14

Absent Amino Acids RNDCQGILKMFSWY

Common Amino Acids EP

Mass 878.94

PI 4.25

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -2

Boman Index 5.94

Hydrophobicity -1.012

Aliphatic Index 48.75

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

2

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

8

Formula

C38H58N10O14

Mass

878.94

PI

4.25

Net Charge

-2

Boman Index

5.94

Hydrophobicity

-1.012

Chemical_Mass

878.9234

Monoisotopic_Mass

878.4120

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 409.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Theysgeur S., Cudennec B., Deracinois B., Perrin C., Guiller I., Lepoudère A., Flahaut C., Ravallec R.

Title

New bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on DPP-IV activity and intestinal hormones regulation after canine gastrointestinal simulated digestion. Molecules, 26, 136, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H]([C@H](O)C)C(=O)O InChI=1S/C38H58N10O14/c1-18(2)29(39)35(58)42-19(3)36(59)47-13-5-7-25(47)33(56)44-23(10-12-28(52)53)31(54)43-22(9-11-27(50)51)32(55)45-24(15-21-16-40-17-41-21)37(60)48-14-6-8-26(48)34(57)46-30(20(4)49)38(61)62/h16-20,22-26,29-30,49H,5-15,39H2,1-4H3,(H,40,41)(H,42,58)(H,43,54)(H,44,56)(H,45,55)(H,46,57)(H,50,51)(H,52,53)(H,61,62)/t19-,20+,22-,23-,24-,25-,26-,29-,30-/m0/s1 InChIKey=ZECYSAJQCPOXKX-ICUBCQCDSA-N

Number_of_Residues

8