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Peptide record

TPDB47377

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47377
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LLNPPHQIYP
Physicochemical Analysis
C57H86N14O14
ARDCEGKMFSTWV
P
1191.40
7.77
1
0
4
+0
0.94
-0.420
117.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
125.06
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
2
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 2 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C57H86N14O14
1191.40
7.77
+0
0.94
-0.420
1191.3747
1190.6428
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C57H86N14O14/c1-7-32(6)47(53(80)67-40(25-33-14-16-35(72)17-15-33)54(81)71-22-10-13-44(71)57(84)85)68-49(76)37(18-19-45(59)73)63-51(78)39(26-34-28-61-29-62-34)65-52(79)42-11-8-20-69(42)56(83)43-12-9-21-70(43)55(82)41(27-46(60)74)66-50(77)38(24-31(4)5)64-48(75)36(58)23-30(2)3/h14-17,28-32,36-44,47,72H,7-13,18-27,58H2,1-6H3,(H2,59,73)(H2,60,74)(H,61,62)(H,63,78)(H,64,75)(H,65,79)(H,66,77)(H,67,80)(H,68,76)(H,84,85)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-,47-/m0/s1 InChIKey=VODPHRABPVOGSC-HEGKZZHWSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C57H86N14O14/c1-7-32(6)47(53(80)67-40(25-33-14-16-35(72)17-15-33)54(81)71-22-10-13-44(71)57(84)85)68-49(76)37(18-19-45(59)73)63-51(78)39(26-34-28-61-29-62-34)65-52(79)42-11-8-20-69(42)56(83)43-12-9-21-70(43)55(82)41(27-46(60)74)66-50(77)38(24-31(4)5)64-48(75)36(58)23-30(2)3/h14-17,28-32,36-44,47,72H,7-13,18-27,58H2,1-6H3,(H2,59,73)(H2,60,74)(H,61,62)(H,63,78)(H,64,75)(H,65,79)(H,66,77)(H,67,80)(H,68,76)(H,84,85)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-,47-/m0/s1 InChIKey=VODPHRABPVOGSC-HEGKZZHWSA-N
Additional Detail Fields 1 fields
10