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Peptide record

TPDB47376

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47376
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LNPPHQIYP
Physicochemical Analysis
C51H75N13O13
ARDCEGKMFSTWV
P
1078.24
7.77
1
0
3
+0
1.50
-0.889
86.67
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
138.19
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
1
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C51H75N13O13
1078.24
7.77
+0
1.50
-0.889
1078.2175
1077.5590
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C51H75N13O13/c1-5-28(4)42(47(72)60-35(22-29-12-14-31(65)15-13-29)48(73)64-20-8-11-39(64)51(76)77)61-44(69)33(16-17-40(53)66)57-45(70)34(23-30-25-55-26-56-30)58-46(71)37-9-6-18-62(37)50(75)38-10-7-19-63(38)49(74)36(24-41(54)67)59-43(68)32(52)21-27(2)3/h12-15,25-28,32-39,42,65H,5-11,16-24,52H2,1-4H3,(H2,53,66)(H2,54,67)(H,55,56)(H,57,70)(H,58,71)(H,59,68)(H,60,72)(H,61,69)(H,76,77)/t28-,32-,33-,34-,35-,36-,37-,38-,39-,42-/m0/s1 InChIKey=KAUBVZLBIKXFGK-SNOMRCCPSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C51H75N13O13/c1-5-28(4)42(47(72)60-35(22-29-12-14-31(65)15-13-29)48(73)64-20-8-11-39(64)51(76)77)61-44(69)33(16-17-40(53)66)57-45(70)34(23-30-25-55-26-56-30)58-46(71)37-9-6-18-62(37)50(75)38-10-7-19-63(38)49(74)36(24-41(54)67)59-43(68)32(52)21-27(2)3/h12-15,25-28,32-39,42,65H,5-11,16-24,52H2,1-4H3,(H2,53,66)(H2,54,67)(H,55,56)(H,57,70)(H,58,71)(H,59,68)(H,60,72)(H,61,69)(H,76,77)/t28-,32-,33-,34-,35-,36-,37-,38-,39-,42-/m0/s1 InChIKey=KAUBVZLBIKXFGK-SNOMRCCPSA-N
Additional Detail Fields 1 fields
9