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Peptide record

TPDB47375

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47375
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
NPPHQIYP
Physicochemical Analysis
C45H64N12O12
ARDCEGLKMFSTWV
P
965.08
7.77
1
0
2
+0
2.06
-1.475
48.75
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
154.39
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C45H64N12O12
965.08
7.77
+0
2.06
-1.475
965.0603
964.4752
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
37.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H64N12O12/c1-3-24(2)37(41(64)53-31(19-25-10-12-27(58)13-11-25)43(66)57-18-6-9-34(57)45(68)69)54-38(61)29(14-15-35(47)59)51-39(62)30(20-26-22-49-23-50-26)52-40(63)32-7-4-16-55(32)44(67)33-8-5-17-56(33)42(65)28(46)21-36(48)60/h10-13,22-24,28-34,37,58H,3-9,14-21,46H2,1-2H3,(H2,47,59)(H2,48,60)(H,49,50)(H,51,62)(H,52,63)(H,53,64)(H,54,61)(H,68,69)/t24-,28-,29-,30-,31-,32-,33-,34-,37-/m0/s1 InChIKey: IFFMIVXMOAYXQC-NJZPZLDLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
37.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H64N12O12/c1-3-24(2)37(41(64)53-31(19-25-10-12-27(58)13-11-25)43(66)57-18-6-9-34(57)45(68)69)54-38(61)29(14-15-35(47)59)51-39(62)30(20-26-22-49-23-50-26)52-40(63)32-7-4-16-55(32)44(67)33-8-5-17-56(33)42(65)28(46)21-36(48)60/h10-13,22-24,28-34,37,58H,3-9,14-21,46H2,1-2H3,(H2,47,59)(H2,48,60)(H,49,50)(H,51,62)(H,52,63)(H,53,64)(H,54,61)(H,68,69)/t24-,28-,29-,30-,31-,32-,33-,34-,37-/m0/s1 InChIKey: IFFMIVXMOAYXQC-NJZPZLDLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
8