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Peptide record

TPDB47374

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47374
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PPHQIYP
Physicochemical Analysis
C41H58N10O10
ARNDCEGLKMFSTWV
P
850.97
7.77
1
0
2
+0
1.64
-1.186
55.71
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
175.09
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C41H58N10O10
850.97
7.77
+0
1.64
-1.186
850.9579
850.4324
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H58N10O10/c1-3-23(2)34(38(57)48-30(19-24-10-12-26(52)13-11-24)40(59)51-18-6-9-32(51)41(60)61)49-35(54)27(14-15-33(42)53)46-36(55)29(20-25-21-43-22-45-25)47-37(56)31-8-5-17-50(31)39(58)28-7-4-16-44-28/h10-13,21-23,27-32,34,44,52H,3-9,14-20H2,1-2H3,(H2,42,53)(H,43,45)(H,46,55)(H,47,56)(H,48,57)(H,49,54)(H,60,61)/t23-,27-,28-,29-,30-,31-,32-,34-/m0/s1 InChIKey=LVLIIMHSNWTICI-LBWFYSSPSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H58N10O10/c1-3-23(2)34(38(57)48-30(19-24-10-12-26(52)13-11-24)40(59)51-18-6-9-32(51)41(60)61)49-35(54)27(14-15-33(42)53)46-36(55)29(20-25-21-43-22-45-25)47-37(56)31-8-5-17-50(31)39(58)28-7-4-16-44-28/h10-13,21-23,27-32,34,44,52H,3-9,14-20H2,1-2H3,(H2,42,53)(H,43,45)(H,46,55)(H,47,56)(H,48,57)(H,49,54)(H,60,61)/t23-,27-,28-,29-,30-,31-,32-,34-/m0/s1 InChIKey=LVLIIMHSNWTICI-LBWFYSSPSA-N
Additional Detail Fields 1 fields
7