Back to search

Peptide record

TPDB47372

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47372
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IPQEVLP
Physicochemical Analysis
C37H62N8O11
ARNDCGHKMFSTWY
P
794.95
3.29
0
1
3
-1
2.70
0.329
152.86
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C37H62N8O11
794.95
3.29
-1
2.70
0.329
794.9327
794.4523
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
690.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@](C(N1CCC[C@]1(C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N1CCC[C@]1(C(O)=O)[H])=O)(CC(C)C)[H])=O)(C(C)C)[H])=O)(CCC(O)=O)[H])=O)(CCC(N)=O)[H])=O)[H])=O)([C@@H](C)CC)[H] InChI=1S/C37H62N8O11/c1-7-21(6)29(39)36(54)44-16-8-10-25(44)33(51)41-22(12-14-27(38)46)31(49)40-23(13-15-28(47)48)32(50)43-30(20(4)5)34(52)42-24(18-19(2)3)35(53)45-17-9-11-26(45)37(55)56/h19-26,29-30H,7-18,39H2,1-6H3,(H2,38,46)(H,40,49)(H,41,51)(H,42,52)(H,43,50)(H,47,48)(H,55,56)/t21-,22-,23-,24-,25-,26-,29-,30-/m0/s1 InChIKey: OGSNUSVFSRWHJQ-QBUMULATSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
690.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@](C(N1CCC[C@]1(C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N1CCC[C@]1(C(O)=O)[H])=O)(CC(C)C)[H])=O)(C(C)C)[H])=O)(CCC(O)=O)[H])=O)(CCC(N)=O)[H])=O)[H])=O)([C@@H](C)CC)[H] InChI=1S/C37H62N8O11/c1-7-21(6)29(39)36(54)44-16-8-10-25(44)33(51)41-22(12-14-27(38)46)31(49)40-23(13-15-28(47)48)32(50)43-30(20(4)5)34(52)42-24(18-19(2)3)35(53)45-17-9-11-26(45)37(55)56/h19-26,29-30H,7-18,39H2,1-6H3,(H2,38,46)(H,40,49)(H,41,51)(H,42,52)(H,43,50)(H,47,48)(H,55,56)/t21-,22-,23-,24-,25-,26-,29-,30-/m0/s1 InChIKey: OGSNUSVFSRWHJQ-QBUMULATSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7