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Peptide record

TPDB47371

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47371
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
QVPQPIP
Physicochemical Analysis
C36H59N9O10
ARNDCEGHLKMFSTWY
P
777.92
6.02
0
0
2
-0
2.27
-0.443
97.14
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C36H59N9O10
777.92
6.02
-0
2.27
-0.443
777.9056
777.4371
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
660.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H59N9O10/c1-5-20(4)29(35(53)45-18-8-11-25(45)36(54)55)42-32(50)24-10-6-16-43(24)33(51)22(13-15-27(39)47)40-31(49)23-9-7-17-44(23)34(52)28(19(2)3)41-30(48)21(37)12-14-26(38)46/h19-25,28-29H,5-18,37H2,1-4H3,(H2,38,46)(H2,39,47)(H,40,49)(H,41,48)(H,42,50)(H,54,55)/t20-,21-,22-,23-,24-,25-,28-,29-/m0/s1 InChIKey: FLNGIYOYNRBCLT-OUGWIXDFSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
660.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C36H59N9O10/c1-5-20(4)29(35(53)45-18-8-11-25(45)36(54)55)42-32(50)24-10-6-16-43(24)33(51)22(13-15-27(39)47)40-31(49)23-9-7-17-44(23)34(52)28(19(2)3)41-30(48)21(37)12-14-26(38)46/h19-25,28-29H,5-18,37H2,1-4H3,(H2,38,46)(H2,39,47)(H,40,49)(H,41,48)(H,42,50)(H,54,55)/t20-,21-,22-,23-,24-,25-,28-,29-/m0/s1 InChIKey: FLNGIYOYNRBCLT-OUGWIXDFSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7