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Peptide record

TPDB47370

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47370
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LENLHLPLP
Physicochemical Analysis
C49H80N12O13
ARDCQGIKMFSTWYV
L
1045.25
5.13
1
1
4
-1
2.06
0.200
173.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
4
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 4 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C49H80N12O13
1045.25
5.13
-1
2.06
0.200
1045.2289
1044.5949
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
86.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

9
BIOPEP-UWN database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C49H80N12O13/c1-25(2)17-30(50)41(65)54-31(13-14-40(63)64)42(66)57-34(22-39(51)62)45(69)55-32(18-26(3)4)43(67)56-33(21-29-23-52-24-53-29)44(68)58-35(19-27(5)6)47(71)60-15-9-11-37(60)46(70)59-36(20-28(7)8)48(72)61-16-10-12-38(61)49(73)74/h23-28,30-38H,9-22,50H2,1-8H3,(H2,51,62)(H,52,53)(H,54,65)(H,55,69)(H,56,67)(H,57,66)(H,58,68)(H,59,70)(H,63,64)(H,73,74)/t30-,31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey: RFAVCANCGUGWMW-IWLMWFOOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
86.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWN database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C49H80N12O13/c1-25(2)17-30(50)41(65)54-31(13-14-40(63)64)42(66)57-34(22-39(51)62)45(69)55-32(18-26(3)4)43(67)56-33(21-29-23-52-24-53-29)44(68)58-35(19-27(5)6)47(71)60-15-9-11-37(60)46(70)59-36(20-28(7)8)48(72)61-16-10-12-38(61)49(73)74/h23-28,30-38H,9-22,50H2,1-8H3,(H2,51,62)(H,52,53)(H,54,65)(H,55,69)(H,56,67)(H,57,66)(H,58,68)(H,59,70)(H,63,64)(H,73,74)/t30-,31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey: RFAVCANCGUGWMW-IWLMWFOOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
9