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Peptide record

TPDB47366

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47366
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PFFDPQIP
Physicochemical Analysis
C48H65N9O12
ARNCEGHLKMSTWYV
P
960.10
3.10
0
1
3
-1
0.59
-0.213
48.75
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
2
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 2 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H65N9O12
960.10
3.10
-1
0.59
-0.213
960.0802
959.4737
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C48H65N9O12/c1-3-28(2)40(47(67)57-24-12-19-37(57)48(68)69)55-42(62)32(20-21-38(49)58)51-45(65)36-18-11-23-56(36)46(66)35(27-39(59)60)54-44(64)34(26-30-15-8-5-9-16-30)53-43(63)33(25-29-13-6-4-7-14-29)52-41(61)31-17-10-22-50-31/h4-9,13-16,28,31-37,40,50H,3,10-12,17-27H2,1-2H3,(H2,49,58)(H,51,65)(H,52,61)(H,53,63)(H,54,64)(H,55,62)(H,59,60) InChIKey=CKCAROOYFWXEDH-QMTXDJFOSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C48H65N9O12/c1-3-28(2)40(47(67)57-24-12-19-37(57)48(68)69)55-42(62)32(20-21-38(49)58)51-45(65)36-18-11-23-56(36)46(66)35(27-39(59)60)54-44(64)34(26-30-15-8-5-9-16-30)53-43(63)33(25-29-13-6-4-7-14-29)52-41(61)31-17-10-22-50-31/h4-9,13-16,28,31-37,40,50H,3,10-12,17-27H2,1-2H3,(H2,49,58)(H,51,65)(H,52,61)(H,53,63)(H,54,64)(H,55,62)(H,59,60) InChIKey=CKCAROOYFWXEDH-QMTXDJFOSA-N
Additional Detail Fields 1 fields
8