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Peptide record

TPDB47365

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47365
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
TVYTKGRVMP
Physicochemical Analysis
C51H86N14O14S1
ANDCEQHILFSW
TV
1151.39
10.42
2
0
4
+2
1.51
-0.280
58.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
129.41
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
1
M
0
F
1
P
0
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
10
C51H86N14O14S1
1151.39
10.42
+2
1.51
-0.280
1151.3766
1150.6149
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
38.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)
1989
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)O InChI=1S/C51H86N14O14S/c1-26(2)39(46(74)60-34(19-23-80-7)49(77)65-22-11-14-36(65)50(78)79)62-43(71)33(13-10-21-56-51(54)55)58-37(69)25-57-42(70)32(12-8-9-20-52)59-48(76)41(29(6)67)64-44(72)35(24-30-15-17-31(68)18-16-30)61-47(75)40(27(3)4)63-45(73)38(53)28(5)66/h15-18,26-29,32-36,38-41,66-68H,8-14,19-25,52-53H2,1-7H3,(H,57,70)(H,58,69)(H,59,76)(H,60,74)(H,61,75)(H,62,71)(H,63,73)(H,64,72)(H,78,79)(H4,54,55,56)/t28-,29-,32+,33+,34+,35+,36+,38+,39+,40+,41+/m1/s1 InChIKey=VOTVRSWNNVBBHR-OJUFOGIPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
38.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)O InChI=1S/C51H86N14O14S/c1-26(2)39(46(74)60-34(19-23-80-7)49(77)65-22-11-14-36(65)50(78)79)62-43(71)33(13-10-21-56-51(54)55)58-37(69)25-57-42(70)32(12-8-9-20-52)59-48(76)41(29(6)67)64-44(72)35(24-30-15-17-31(68)18-16-30)61-47(75)40(27(3)4)63-45(73)38(53)28(5)66/h15-18,26-29,32-36,38-41,66-68H,8-14,19-25,52-53H2,1-7H3,(H,57,70)(H,58,69)(H,59,76)(H,60,74)(H,61,75)(H,62,71)(H,63,73)(H,64,72)(H,78,79)(H4,54,55,56)/t28-,29-,32+,33+,34+,35+,36+,38+,39+,40+,41+/m1/s1 InChIKey=VOTVRSWNNVBBHR-OJUFOGIPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001
Additional Detail Fields 1 fields
10