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Peptide record

TPDB47364

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47364
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LPQNILP
Physicochemical Analysis
C37H63N9O10
ARDCEGHKMFSTWYV
LP
793.96
6.02
0
0
3
-0
0.47
0.271
167.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
2
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C37H63N9O10
793.96
6.02
-0
0.47
0.271
793.9479
793.4683
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
46.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C37H63N9O10/c1-7-21(6)30(34(52)43-25(17-20(4)5)36(54)46-15-9-11-27(46)37(55)56)44-32(50)24(18-29(40)48)42-31(49)23(12-13-28(39)47)41-33(51)26-10-8-14-45(26)35(53)22(38)16-19(2)3/h19-27,30H,7-18,38H2,1-6H3,(H2,39,47)(H2,40,48)(H,41,51)(H,42,49)(H,43,52)(H,44,50)(H,55,56)/t21-,22-,23-,24-,25-,26-,27-,30-/m0/s1 InChIKey=QWBOVIJRGTYFII-IIBWBHLISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
46.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C37H63N9O10/c1-7-21(6)30(34(52)43-25(17-20(4)5)36(54)46-15-9-11-27(46)37(55)56)44-32(50)24(18-29(40)48)42-31(49)23(12-13-28(39)47)41-33(51)26-10-8-14-45(26)35(53)22(38)16-19(2)3/h19-27,30H,7-18,38H2,1-6H3,(H2,39,47)(H2,40,48)(H,41,51)(H,42,49)(H,43,52)(H,44,50)(H,55,56)/t21-,22-,23-,24-,25-,26-,27-,30-/m0/s1 InChIKey=QWBOVIJRGTYFII-IIBWBHLISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7