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Peptide record

TPDB47363

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47363
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
EPIPYGFLP
Physicochemical Analysis
C52H73N9O13
ARNDCQHKMSTWV
P
1032.20
3.29
0
1
4
-1
0.44
0.122
86.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1490
144.35
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C52H73N9O13
1032.20
3.29
-1
0.44
0.122
1032.1856
1031.5310
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
180.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C52H73N9O13/c1-5-31(4)44(58-48(69)40-15-9-23-59(40)49(70)35(53)21-22-43(64)65)51(72)60-24-10-14-39(60)47(68)56-36(28-33-17-19-34(62)20-18-33)45(66)54-29-42(63)55-37(27-32-12-7-6-8-13-32)46(67)57-38(26-30(2)3)50(71)61-25-11-16-41(61)52(73)74/h6-8,12-13,17-20,30-31,35-41,44,62H,5,9-11,14-16,21-29,53H2,1-4H3,(H,54,66)(H,55,63)(H,56,68)(H,57,67)(H,58,69)(H,64,65)(H,73,74)/t31-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1 InChIKey: PLXVFCQBDDCMPL-XHDPZWPTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
180.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C52H73N9O13/c1-5-31(4)44(58-48(69)40-15-9-23-59(40)49(70)35(53)21-22-43(64)65)51(72)60-24-10-14-39(60)47(68)56-36(28-33-17-19-34(62)20-18-33)45(66)54-29-42(63)55-37(27-32-12-7-6-8-13-32)46(67)57-38(26-30(2)3)50(71)61-25-11-16-41(61)52(73)74/h6-8,12-13,17-20,30-31,35-41,44,62H,5,9-11,14-16,21-29,53H2,1-4H3,(H,54,66)(H,55,63)(H,56,68)(H,57,67)(H,58,69)(H,64,65)(H,73,74)/t31-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1 InChIKey: PLXVFCQBDDCMPL-XHDPZWPTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
9