Back to search

Peptide record

TPDB47359

ACE inhibitor ACE inhibitors Antihypertensive standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47359
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 14-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
KIYPSFQPQPLIYP
Physicochemical Analysis
C84H123N17O20
ARNDCEGHMTWV
P
1691.00
9.56
1
0
6
+1
-0.11
-0.364
83.57
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
176.23
5
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
1
L
1
K
0
M
1
F
4
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
14
C84H123N17O20
1691.00
9.56
+1
-0.11
-0.364
1690.9724
1689.9101
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

14
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C84H123N17O20/c1-7-48(5)69(96-71(107)55(86)20-12-13-37-85)78(114)93-60(44-51-25-29-53(103)30-26-51)82(118)100-40-16-23-65(100)77(113)95-62(46-102)74(110)91-59(43-50-18-10-9-11-19-50)72(108)89-56(33-35-67(87)105)80(116)98-38-14-21-63(98)75(111)90-57(34-36-68(88)106)81(117)99-39-15-22-64(99)76(112)92-58(42-47(3)4)73(109)97-70(49(6)8-2)79(115)94-61(45-52-27-31-54(104)32-28-52)83(119)101-41-17-24-66(101)84(120)121/h9-11,18-19,25-32,47-49,55-66,69-70,102-104H,7-8,12-17,20-24,33-46,85-86H2,1-6H3,(H2,87,105)(H2,88,106)(H,89,108)(H,90,111)(H,91,110)(H,92,112)(H,93,114)(H,94,115)(H,95,113)(H,96,107)(H,97,109)(H,120,121)/t48-,49-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,69-,70-/m0/s1 InChIKey: RTSOCYWPJUHTGE-JGLPHWPASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
8.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
14
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C84H123N17O20/c1-7-48(5)69(96-71(107)55(86)20-12-13-37-85)78(114)93-60(44-51-25-29-53(103)30-26-51)82(118)100-40-16-23-65(100)77(113)95-62(46-102)74(110)91-59(43-50-18-10-9-11-19-50)72(108)89-56(33-35-67(87)105)80(116)98-38-14-21-63(98)75(111)90-57(34-36-68(88)106)81(117)99-39-15-22-64(99)76(112)92-58(42-47(3)4)73(109)97-70(49(6)8-2)79(115)94-61(45-52-27-31-54(104)32-28-52)83(119)101-41-17-24-66(101)84(120)121/h9-11,18-19,25-32,47-49,55-66,69-70,102-104H,7-8,12-17,20-24,33-46,85-86H2,1-6H3,(H2,87,105)(H2,88,106)(H,89,108)(H,90,111)(H,91,110)(H,92,112)(H,93,114)(H,94,115)(H,95,113)(H,96,107)(H,97,109)(H,120,121)/t48-,49-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,69-,70-/m0/s1 InChIKey: RTSOCYWPJUHTGE-JGLPHWPASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
14