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Peptide record

TPDB47358

ACE inhibitor ACE inhibitors Antihypertensive standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB47358
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 13-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IYPSFQPQPLIYP
Physicochemical Analysis
C78H111N15O19
ARNDCEGHKMTWV
P
1562.83
5.88
0
0
6
-0
-1.10
-0.092
90.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
2980
190.68
5
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
1
L
0
K
0
M
1
F
4
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
13
C78H111N15O19
1562.83
5.88
-0
-1.10
-0.092
1562.8006
1561.8154
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C78H111N15O19/c1-7-44(5)64(81)72(105)86-55(40-47-22-26-49(95)27-23-47)76(109)92-36-14-20-60(92)71(104)88-57(42-94)68(101)84-54(39-46-16-10-9-11-17-46)66(99)82-51(30-32-62(79)97)74(107)90-34-12-18-58(90)69(102)83-52(31-33-63(80)98)75(108)91-35-13-19-59(91)70(103)85-53(38-43(3)4)67(100)89-65(45(6)8-2)73(106)87-56(41-48-24-28-50(96)29-25-48)77(110)93-37-15-21-61(93)78(111)112/h9-11,16-17,22-29,43-45,51-61,64-65,94-96H,7-8,12-15,18-21,30-42,81H2,1-6H3,(H2,79,97)(H2,80,98)(H,82,99)(H,83,102)(H,84,101)(H,85,103)(H,86,105)(H,87,106)(H,88,104)(H,89,100)(H,111,112)/t44-,45-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 InChIKey: XQVQYTISIDKNKL-ODAWWGDTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
7.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
13
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C78H111N15O19/c1-7-44(5)64(81)72(105)86-55(40-47-22-26-49(95)27-23-47)76(109)92-36-14-20-60(92)71(104)88-57(42-94)68(101)84-54(39-46-16-10-9-11-17-46)66(99)82-51(30-32-62(79)97)74(107)90-34-12-18-58(90)69(102)83-52(31-33-63(80)98)75(108)91-35-13-19-59(91)70(103)85-53(38-43(3)4)67(100)89-65(45(6)8-2)73(106)87-56(41-48-24-28-50(96)29-25-48)77(110)93-37-15-21-61(93)78(111)112/h9-11,16-17,22-29,43-45,51-61,64-65,94-96H,7-8,12-15,18-21,30-42,81H2,1-6H3,(H2,79,97)(H2,80,98)(H,82,99)(H,83,102)(H,84,101)(H,85,103)(H,86,105)(H,87,106)(H,88,104)(H,89,100)(H,111,112)/t44-,45-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 InChIKey: XQVQYTISIDKNKL-ODAWWGDTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
13