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Peptide record

TPDB47357

ACE inhibitor ACE inhibitors Antihypertensive standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB47357
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 12-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
YPSFQPQPLIYP
Physicochemical Analysis
C72H100N14O18
ARNDCEGHKMTWV
P
1449.67
5.88
0
0
5
-0
-0.79
-0.475
65.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
205.56
5
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
4
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
12
C72H100N14O18
1449.67
5.88
-0
-0.79
-0.475
1449.6434
1448.7316
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
4.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

12
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C72H100N14O18/c1-5-41(4)60(67(98)80-52(38-44-21-25-46(89)26-22-44)71(102)86-34-12-18-57(86)72(103)104)82-62(93)50(35-40(2)3)79-65(96)56-17-11-33-85(56)70(101)49(28-30-59(75)91)77-64(95)55-16-10-32-84(55)69(100)48(27-29-58(74)90)76-61(92)51(37-42-13-7-6-8-14-42)78-63(94)53(39-87)81-66(97)54-15-9-31-83(54)68(99)47(73)36-43-19-23-45(88)24-20-43/h6-8,13-14,19-26,40-41,47-57,60,87-89H,5,9-12,15-18,27-39,73H2,1-4H3,(H2,74,90)(H2,75,91)(H,76,92)(H,77,95)(H,78,94)(H,79,96)(H,80,98)(H,81,97)(H,82,93)(H,103,104)/t41-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,60-/m0/s1 InChIKey: HETIQKPZTQCCPC-ARNPNECASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
4.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
12
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C72H100N14O18/c1-5-41(4)60(67(98)80-52(38-44-21-25-46(89)26-22-44)71(102)86-34-12-18-57(86)72(103)104)82-62(93)50(35-40(2)3)79-65(96)56-17-11-33-85(56)70(101)49(28-30-59(75)91)77-64(95)55-16-10-32-84(55)69(100)48(27-29-58(74)90)76-61(92)51(37-42-13-7-6-8-14-42)78-63(94)53(39-87)81-66(97)54-15-9-31-83(54)68(99)47(73)36-43-19-23-45(88)24-20-43/h6-8,13-14,19-26,40-41,47-57,60,87-89H,5,9-12,15-18,27-39,73H2,1-4H3,(H2,74,90)(H2,75,91)(H,76,92)(H,77,95)(H,78,94)(H,79,96)(H,80,98)(H,81,97)(H,82,93)(H,103,104)/t41-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,60-/m0/s1 InChIKey: HETIQKPZTQCCPC-ARNPNECASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
12