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Peptide record

TPDB47356

ACE inhibitor ACE inhibitors Antihypertensive standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB47356
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PSFQPQPLIYP
Physicochemical Analysis
C63H91N13O16
ARNDCEGHKMTWV
P
1286.49
5.94
0
0
4
-0
0.15
-0.400
70.91
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
115.82
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
4
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C63H91N13O16
1286.49
5.94
-0
0.15
-0.400
1286.4705
1285.6685
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CO)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C63H91N13O16/c1-5-36(4)52(59(87)71-45(33-38-19-21-39(78)22-20-38)62(90)76-30-12-18-49(76)63(91)92)73-55(83)43(31-35(2)3)70-58(86)48-17-11-29-75(48)61(89)42(24-26-51(65)80)68-57(85)47-16-10-28-74(47)60(88)41(23-25-50(64)79)67-54(82)44(32-37-13-7-6-8-14-37)69-56(84)46(34-77)72-53(81)40-15-9-27-66-40/h6-8,13-14,19-22,35-36,40-49,52,66,77-78H,5,9-12,15-18,23-34H2,1-4H3,(H2,64,79)(H2,65,80)(H,67,82)(H,68,85)(H,69,84)(H,70,86)(H,71,87)(H,72,81)(H,73,83)(H,91,92)/t36-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,52-/m0/s1 InChIKey: YEBAROZFIOJDOC-OQUSHECLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CO)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C63H91N13O16/c1-5-36(4)52(59(87)71-45(33-38-19-21-39(78)22-20-38)62(90)76-30-12-18-49(76)63(91)92)73-55(83)43(31-35(2)3)70-58(86)48-17-11-29-75(48)61(89)42(24-26-51(65)80)68-57(85)47-16-10-28-74(47)60(88)41(23-25-50(64)79)67-54(82)44(32-37-13-7-6-8-14-37)69-56(84)46(34-77)72-53(81)40-15-9-27-66-40/h6-8,13-14,19-22,35-36,40-49,52,66,77-78H,5,9-12,15-18,23-34H2,1-4H3,(H2,64,79)(H2,65,80)(H,67,82)(H,68,85)(H,69,84)(H,70,86)(H,71,87)(H,72,81)(H,73,83)(H,91,92)/t36-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,52-/m0/s1 InChIKey: YEBAROZFIOJDOC-OQUSHECLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
11