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Peptide record

TPDB47355

ACE inhibitor ACE inhibitors Antihypertensive standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB47355
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
SFQPQPLIYP
Physicochemical Analysis
C58H84N12O15
ARNDCEGHKMTWV
P
1189.38
5.94
0
0
4
-0
-0.30
-0.280
78.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
125.28
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
3
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C58H84N12O15
1189.38
5.94
-0
-0.30
-0.280
1189.3556
1188.6159
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.40 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C58H84N12O15/c1-5-33(4)48(54(80)66-42(30-35-17-19-36(72)20-18-35)57(83)70-27-11-16-45(70)58(84)85)67-51(77)40(28-32(2)3)65-53(79)44-15-10-26-69(44)56(82)39(22-24-47(61)74)63-52(78)43-14-9-25-68(43)55(81)38(21-23-46(60)73)62-50(76)41(64-49(75)37(59)31-71)29-34-12-7-6-8-13-34/h6-8,12-13,17-20,32-33,37-45,48,71-72H,5,9-11,14-16,21-31,59H2,1-4H3,(H2,60,73)(H2,61,74)(H,62,76)(H,63,78)(H,64,75)(H,65,79)(H,66,80)(H,67,77)(H,84,85)/t33-,37-,38-,39-,40-,41-,42-,43-,44-,45-,48-/m0/s1 InChIKey=VECYLVVDTMOQLJ-BMEMEHQISA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.40 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C58H84N12O15/c1-5-33(4)48(54(80)66-42(30-35-17-19-36(72)20-18-35)57(83)70-27-11-16-45(70)58(84)85)67-51(77)40(28-32(2)3)65-53(79)44-15-10-26-69(44)56(82)39(22-24-47(61)74)63-52(78)43-14-9-25-68(43)55(81)38(21-23-46(60)73)62-50(76)41(64-49(75)37(59)31-71)29-34-12-7-6-8-13-34/h6-8,12-13,17-20,32-33,37-45,48,71-72H,5,9-11,14-16,21-31,59H2,1-4H3,(H2,60,73)(H2,61,74)(H,62,76)(H,63,78)(H,64,75)(H,65,79)(H,66,80)(H,67,77)(H,84,85)/t33-,37-,38-,39-,40-,41-,42-,43-,44-,45-,48-/m0/s1 InChIKey=VECYLVVDTMOQLJ-BMEMEHQISA-N
Additional Detail Fields 1 fields
10