Back to search

Peptide record

TPDB47354

ACE inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47354
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FQPQPLIYP
Physicochemical Analysis
C55H79N11O13
ARNDCEGHKMSTWV
P
1102.30
5.94
0
0
4
-0
-0.43
-0.222
86.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
135.17
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C55H79N11O13
1102.30
5.94
-0
-0.43
-0.222
1102.2785
1101.5840
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C55H79N11O13/c1-5-32(4)46(51(74)62-40(30-34-17-19-35(67)20-18-34)54(77)66-27-11-16-43(66)55(78)79)63-48(71)39(28-31(2)3)61-50(73)42-15-10-26-65(42)53(76)38(22-24-45(58)69)60-49(72)41-14-9-25-64(41)52(75)37(21-23-44(57)68)59-47(70)36(56)29-33-12-7-6-8-13-33/h6-8,12-13,17-20,31-32,36-43,46,67H,5,9-11,14-16,21-30,56H2,1-4H3,(H2,57,68)(H2,58,69)(H,59,70)(H,60,72)(H,61,73)(H,62,74)(H,63,71)(H,78,79)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,46-/m0/s1 InChIKey: SYRRWUCIBUUVIA-STNLWWJWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C55H79N11O13/c1-5-32(4)46(51(74)62-40(30-34-17-19-35(67)20-18-34)54(77)66-27-11-16-43(66)55(78)79)63-48(71)39(28-31(2)3)61-50(73)42-15-10-26-65(42)53(76)38(22-24-45(58)69)60-49(72)41-14-9-25-64(41)52(75)37(21-23-44(57)68)59-47(70)36(56)29-33-12-7-6-8-13-33/h6-8,12-13,17-20,31-32,36-43,46,67H,5,9-11,14-16,21-30,56H2,1-4H3,(H2,57,68)(H2,58,69)(H,59,70)(H,60,72)(H,61,73)(H,62,74)(H,63,71)(H,78,79)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,46-/m0/s1 InChIKey: SYRRWUCIBUUVIA-STNLWWJWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
9