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Peptide record

TPDB47353

ACE inhibitor ACE inhibitors Antihypertensive standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB47353
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
QPQPLIYP
Physicochemical Analysis
C46H70N10O12
ARNDCEGHKMFSTWV
P
955.12
5.94
0
0
3
-0
0.70
-0.600
97.50
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1490
156.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C46H70N10O12
955.12
5.94
-0
0.70
-0.600
955.1050
954.5158
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
4.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C46H70N10O12/c1-5-26(4)38(42(63)52-32(24-27-12-14-28(57)15-13-27)45(66)56-22-8-11-35(56)46(67)68)53-39(60)31(23-25(2)3)51-41(62)34-10-7-21-55(34)44(65)30(17-19-37(49)59)50-40(61)33-9-6-20-54(33)43(64)29(47)16-18-36(48)58/h12-15,25-26,29-35,38,57H,5-11,16-24,47H2,1-4H3,(H2,48,58)(H2,49,59)(H,50,61)(H,51,62)(H,52,63)(H,53,60)(H,67,68)/t26-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey: WTJUWXYRNVDNPM-NGLZDHJISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
4.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C46H70N10O12/c1-5-26(4)38(42(63)52-32(24-27-12-14-28(57)15-13-27)45(66)56-22-8-11-35(56)46(67)68)53-39(60)31(23-25(2)3)51-41(62)34-10-7-21-55(34)44(65)30(17-19-37(49)59)50-40(61)33-9-6-20-54(33)43(64)29(47)16-18-36(48)58/h12-15,25-26,29-35,38,57H,5-11,16-24,47H2,1-4H3,(H2,48,58)(H2,49,59)(H,50,61)(H,51,62)(H,52,63)(H,53,60)(H,67,68)/t26-,29-,30-,31-,32-,33-,34-,35-,38-/m0/s1 InChIKey: WTJUWXYRNVDNPM-NGLZDHJISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
8