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Peptide record

TPDB47352

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47352
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PQPLIYP
Physicochemical Analysis
C41H62N8O10
ARNDCEGHKMFSTWV
P
826.99
5.94
0
0
3
-0
0.12
-0.186
111.43
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
180.17
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C41H62N8O10
826.99
5.94
-0
0.12
-0.186
826.9761
826.4574
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
3.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H62N8O10/c1-5-24(4)34(38(55)46-30(22-25-12-14-26(50)15-13-25)40(57)49-20-8-11-32(49)41(58)59)47-36(53)29(21-23(2)3)45-37(54)31-10-7-19-48(31)39(56)28(16-17-33(42)51)44-35(52)27-9-6-18-43-27/h12-15,23-24,27-32,34,43,50H,5-11,16-22H2,1-4H3,(H2,42,51)(H,44,52)(H,45,54)(H,46,55)(H,47,53)(H,58,59)/t24-,27-,28-,29-,30-,31-,32-,34-/m0/s1 InChIKey: SIJAFMHBCSPOGZ-VILALIAOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

EC50
Antihypertensive
3.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C41H62N8O10/c1-5-24(4)34(38(55)46-30(22-25-12-14-26(50)15-13-25)40(57)49-20-8-11-32(49)41(58)59)47-36(53)29(21-23(2)3)45-37(54)31-10-7-19-48(31)39(56)28(16-17-33(42)51)44-35(52)27-9-6-18-43-27/h12-15,23-24,27-32,34,43,50H,5-11,16-22H2,1-4H3,(H2,42,51)(H,44,52)(H,45,54)(H,46,55)(H,47,53)(H,58,59)/t24-,27-,28-,29-,30-,31-,32-,34-/m0/s1 InChIKey: SIJAFMHBCSPOGZ-VILALIAOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7