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Peptide record

TPDB47348

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive iDPPIV standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB47348
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive iDPPIV
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IPPLTQTPV
Physicochemical Analysis
C45H76N10O13
ARNDCEGHKMFSWY
P
965.16
6.02
0
0
3
-0
1.41
0.311
118.89
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
3
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 3 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C45H76N10O13
965.16
6.02
-0
1.41
0.311
965.1411
964.5575
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gobbetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Appl. Env. Microbiol., 66, 3898-3904, 2000
2000
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C45H76N10O13/c1-9-24(6)33(47)43(65)55-20-12-15-31(55)42(64)53-18-10-13-29(53)39(61)49-28(21-22(2)3)38(60)51-35(25(7)56)41(63)48-27(16-17-32(46)58)37(59)52-36(26(8)57)44(66)54-19-11-14-30(54)40(62)50-34(23(4)5)45(67)68/h22-31,33-36,56-57H,9-21,47H2,1-8H3,(H2,46,58)(H,48,63)(H,49,61)(H,50,62)(H,51,60)(H,52,59)(H,67,68)/t24-,25+,26+,27-,28-,29-,30-,31-,33-,34-,35-,36-/m0/s1 InChIKey=NUUZJLGEZRQVGA-DOCGQKLASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8660), the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gobbetti M., Ferranti P., Smacchi E., Goffredi F., Addeo F.
Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Appl. Env. Microbiol., 66, 3898-3904, 2000
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C45H76N10O13/c1-9-24(6)33(47)43(65)55-20-12-15-31(55)42(64)53-18-10-13-29(53)39(61)49-28(21-22(2)3)38(60)51-35(25(7)56)41(63)48-27(16-17-32(46)58)37(59)52-36(26(8)57)44(66)54-19-11-14-30(54)40(62)50-34(23(4)5)45(67)68/h22-31,33-36,56-57H,9-21,47H2,1-8H3,(H2,46,58)(H,48,63)(H,49,61)(H,50,62)(H,51,60)(H,52,59)(H,67,68)/t24-,25+,26+,27-,28-,29-,30-,31-,33-,34-,35-,36-/m0/s1 InChIKey=NUUZJLGEZRQVGA-DOCGQKLASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8660), the EROP-Moscow database
Evidence 3 Activity

Activity

IC50
iDPPIV
1300.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Uenishi H., Kabuki T., Seto Y., Serizawa A., Nakajima H.
Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. Int. Dairy J., 22, 24-30, 2012
2012
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C45H76N10O13/c1-9-24(6)33(47)43(65)55-20-12-15-31(55)42(64)53-18-10-13-29(53)39(61)49-28(21-22(2)3)38(60)51-35(25(7)56)41(63)48-27(16-17-32(46)58)37(59)52-36(26(8)57)44(66)54-19-11-14-30(54)40(62)50-34(23(4)5)45(67)68/h22-31,33-36,56-57H,9-21,47H2,1-8H3,(H2,46,58)(H,48,63)(H,49,61)(H,50,62)(H,51,60)(H,52,59)(H,67,68)/t24-,25+,26+,27-,28-,29-,30-,31-,33-,34-,35-,36-/m0/s1 InChIKey=NUUZJLGEZRQVGA-DOCGQKLASA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (I 10099), the EROP-Moscow database
Additional Detail Fields 1 fields
9