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Peptide record

TPDB47346

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antihypertensive Umami iDPPIV standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB47346
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antihypertensive Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
AHTPDB AHTpin Peptipedia Tastepeptides-Meta iDPPIV pep-lab
standard
No
A 7-aa standard natural multi-activity (Antihypertensive, Umami, and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GPFPILV
Physicochemical Analysis
C38H59N7O8
ARNDCEQHKMSTWY
P
741.93
6.02
0
0
4
-0
-1.02
1.671
152.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C38H59N7O8
741.93
6.02
-0
-1.02
1.671
741.9148
741.4411
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
424.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Quirós A., Hernández-Ledesma B., Ramos M., Amigo L., Recio I.
Angiotensin-converting enzyme inhibitory activity of peptides derived from caprine kefir. J. Dairy Sci., 88, 3480-3487, 2005
2005
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CC(C)C)[C@H](CC)C)CCC2)Cc2ccccc2)CCC1 InChI=1S/C38H59N7O8/c1-7-24(6)32(36(50)40-26(19-22(2)3)33(47)42-31(23(4)5)38(52)53)43-35(49)29-16-12-18-45(29)37(51)27(20-25-13-9-8-10-14-25)41-34(48)28-15-11-17-44(28)30(46)21-39/h8-10,13-14,22-24,26-29,31-32H,7,11-12,15-21,39H2,1-6H3,(H,40,50)(H,41,48)(H,42,47)(H,43,49)(H,52,53)/t24-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey=DASCHEQGEKYNTI-YUQDWORRSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9128) the DFBP database the EROP-Moscow database the MBPDB database
Evidence 2 Activity

Activity

IC50
iDPPIV
163.70 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Zhang Y., Chen R., Zuo F., Ma H., Zhang Y., Chen S.
Comparison of dipeptidyl peptidase IV-inhibitory activity of peptides from bovine and caprine milk casein by in silico and in vitro analyses. Int. Dairy J., 53, 37-44, 2016
2016
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CC(C)C)[C@H](CC)C)CCC2)Cc2ccccc2)CCC1 InChI=1S/C38H59N7O8/c1-7-24(6)32(36(50)40-26(19-22(2)3)33(47)42-31(23(4)5)38(52)53)43-35(49)29-16-12-18-45(29)37(51)27(20-25-13-9-8-10-14-25)41-34(48)28-15-11-17-44(28)30(46)21-39/h8-10,13-14,22-24,26-29,31-32H,7,11-12,15-21,39H2,1-6H3,(H,40,50)(H,41,48)(H,42,47)(H,43,49)(H,52,53)/t24-,26-,27-,28-,29-,31-,32-/m0/s1 InChIKey: DASCHEQGEKYNTI-YUQDWORRSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the MBPDB database
Additional Detail Fields 1 fields
7